RELATED: If You’ve Taken Tylenol With These Common OTC Meds, Get Your Liver Checked. Peripheral arterial disease (PAD) is a serious chronic condition that causes narrowing of the arteries. This happens as a result of atherosclerosis, a process by which fatty plaques build up inside of the arteries, resulting in poor circulation. The condition currently affects between eight to 12 million people in the U.S., according to the National Institutes of Health.ae0fcc31ae342fd3a1346ebb1f342fcb People with PAD often experience symptoms in their legs and arms, including pain, cramping, weakness, numbness, and more. However, it can also have serious implications for your broader health. Because the same fatty deposits that cause PAD can also cause blot clots, people with the condition are at heightened risk of limb amputation, heart attack, and stroke. RELATED: Never Take These 2 Common OTC Medications at Once, Experts Warn. There are several lifestyle factors that can worsen your PAD symptoms—tobacco use, maintaining a poor diet, and leading a sedentary lifestyle, to name a few. But there’s one other lesser-known factor that could be putting you at risk—and it may be hiding in your medicine cabinet. The Mayo Clinic says if you have peripheral arterial disease, it’s important to avoid certain cold medications. In particular, you should be wary of “over-the-counter cold remedies that contain pseudoephedrine (Advil Cold & Sinus, Aleve-D Sinus & Cold, others)” which they warn “may increase your PAD symptoms.” Certain allergy medications, such as Mucinex-D and Claritin-D, also contain pseudoephedrine. Pseudoephedrine works to ease decongestion by constricting the blood vessels in the nasal passages and sinuses, slowing mucus production. However, experts from the University of Virginia’s health blog, UVA Health, warn that “those same constricted vessels might also increase your blood pressure and heart rate.” That’s because “pseudoephedrine is chemically similar to adrenaline, so the body recognizes it as adrenaline, causing the blood pressure and heart rate to increase,” pharmacist Kayla Ryan explained via the site. If you’re concerned about your heart health, there are alternative medications available that are made with ingredients that won’t increase blood pressure. “If you’re looking for a safe cold medicine for high blood pressure, consider Coricidin,” UVA experts write. “Coricidin is an over-the-counter multi-symptom product marketed specifically for patients with high blood pressure. It comes in many varieties and contains different active ingredients that target coughs, colds, chest congestion, and allergies.” For more health news sent directly to your inbox, sign up for our daily newsletter.

If you have a known case of peripheral arterial disease, Mayo Clinic experts say it’s a good idea to keep a single running list of any medications, vitamins, and supplements you take, and to take note of the dosage for each. Relaying this information to your doctor can be especially valuable, since they may prescribe additional medication to treat the PAD itself, leading to a heightened risk of dangerous drug interactions. PAD treatment often includes medications to prevent blood clots, lower blood pressure and cholesterol, control pain, and minimize other symptoms. Speak with your doctor or pharmacist if you’re concerned about how your medications may interact—especially if you’ve taken pseudoephedrine-based cold medicines with a known case of PAD—and always be sure to read the labels on both prescription and OTC medications. RELATED: If You’re Over 60, Do Not Take This OTC Medication Every Day, Officials Say.